The production is uncomfortable and artificial, lacking internal logic and tonal consistency.
When film-goers speak of New York-based indies as having become insular and pretentious, "Mistress America" is an example of what they're referring to.
"Self/less" is too badly made to entertain audiences in search of escapist entertainment and too insulting for viewers hoping for more.
Too many elements that made the first film an enjoyable experience are missing.
This isn't cinema; it's vaudeville.
To say this long ride is bumpy would be to understate how uncomfortably tedious the trip is.